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Antigenic Specificity | SENP6 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total SENP6 protein. Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.Dong Ch |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from Internal of human SENP6. |
Other Names | [EC 3.4.22.-; FKSG6; KIAA0797; Protease FKSG6; SEN6] |
Gene, Accession # | [SENP6], Gene ID: 26054, NCBI: NP_001093879.1, UniProt: Q9GZR1 |
Catalog # | MBS9408100 |
Price | $200, $255 |
Order / More Info | SENP6 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |