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Antigenic Specificity | VE-Cadherin (Phospho-Tyr731) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of VE-Cadherin only when phosphorylated at tyrosine 731. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. Wessel F, et al. (2014) Nat Immunol 15, 223-30 Sawada J, et al. (2012) Cancer Cell 22, 235-49 Turowski P, et al |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of Tyrosine731 (H-I-Y(p)-G-Y) derived from Human VE-Cadherin. |
Other Names | [Vascular endothelial cadherin; VE-cadherin; 7B4 antigen; CDH5; CD144 antigen] |
Gene, Accession # | Gene ID: 1003, NCBI: NP_001786.2, UniProt: P33151 |
Catalog # | MBS9411448 |
Price | $200, $255 |
Order / More Info | VE-Cadherin (Phospho-Tyr731) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |