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Antigenic Specificity | NLK - N-terminal region |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This is a rabbit polyclonal antibody against NLK. It was validated on Western BlotTarget Description: NLK is a serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. It is a positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal st |
Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human NLK |
Other Names | [serine/threonine-protein kinase NLK; Serine/threonine-protein kinase NLK; serine/threonine-protein kinase NLK; nemo like kinase; Nemo-like kinase; Protein LAK1] |
Gene, Accession # | [NLK], Gene ID: 51701, NCBI: NP_057315, UniProt: Q9UBE8 |
Catalog # | MBS3219786 |
Price | $335 |
Order / More Info | NLK - N-terminal region Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |