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Antigenic Specificity | BLK |
Clone | polyclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | BLK (B lymphoid tyrosine kinase), with 505-amino acid protein (about 56KDa), belongs to the Src non-receptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR. |
Immunogen | Immunogen: Purified recombinant fragment of BLK expressed in E. Coli. |
Other Names | [MGC10442], [BLK; BLK; MODY11] |
Gene, Accession # | [BLK], Gene ID: 640, NCBI: NP_001706.2, UniProt: P51451 |
Catalog # | MBS850656 |
Price | $280 |
Order / More Info | BLK Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |