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Antigenic Specificity | CBX6 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion. May have a PRC1-independent function in embryonic stem cells. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 80-180 of human CBX6 (NP 055107.3). |
Other Names | [chromobox protein homolog 6 isoform 1; Chromobox protein homolog 6; chromobox protein homolog 6; chromobox 6] |
Gene, Accession # | [CBX6], Gene ID: 23466, NCBI: NP_055107.3, UniProt: O95503 |
Catalog # | MBS8545635 |
Price | $280 |
Order / More Info | CBX6 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |