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Antigenic Specificity | TMP21 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 19 amino acid peptide from near the carboxy terminus of human TMP21. |
Other Names | [Transmembrane emp24 domain-containing protein 10, TMED10] |
Gene, Accession # | [TMP21], Gene ID: 10972, NCBI: AAD31941 |
Catalog # | MBS9407849 |
Price | $320 |
Order / More Info | TMP21 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |