DNMT3A (Center) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | DNMT3A (Center) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human (predicted reactivity: chicken, mouse, rat) |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This DNMT3A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 463-497 amino acids from the Central region of human DNMT3A. Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 |
| Immunogen | n/a |
| Other Names | [DNA (cytosine-5)-methyltransferase 3A; Dnmt3a; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; MHsaIIIA; DNMT3A] |
| Gene, Accession # | [DNMT3A], Gene ID: 1788, NCBI: NP_072046.2, UniProt: Q9Y6K1 |
| Catalog # | MBS9201153 |
| Price | $165, $370 |
| Order / More Info | DNMT3A (Center) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Xie S.,et al.Gene 236:87-95(1999). Chen T.,et al.J. Biol. Chem. 277:38746-38754(2002). Kim G.-D.,et al.EMBO J. 21:4183-4195(2002). Hillier L.W.,et al.Nature 434:724-731(2005). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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