Edit |   |
---|---|
Antigenic Specificity | Phospho-MDM2-S260 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 (1). Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 (2-4). Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53 (3). |
Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding S450 of human MDM2 |
Other Names | [Phospho-MDM2-S260: HDMX; hdm2; ACTFS; MGC5370; MGC71221], [MDM2; MDM2; HDMX; hdm2; ACTFS; Hdm2] |
Gene, Accession # | [MDM2], Gene ID: 4193, NCBI: Q00987.1, UniProt: Q00987 |
Catalog # | MBS125573 |
Price | $235, $350, $525 |
Order / More Info | Phospho-MDM2-S260 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |