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Antigenic Specificity | GRHL2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:25152456). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes. During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure. Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 p |
Immunogen | Immunogen: Recombinant human Grainyhead-like protein 2 homolog protein |
Other Names | [Grainyhead-like protein 2 homolog; Brother of mammalian grainyhead; Transcription factor CP2-like 3; GRHL2; BOM; TFCP2L3], [GRHL2; GRHL2; BOM; ECTDS; DFNA28; TFCP2L3; BOM; TFCP2L3] |
Gene, Accession # | [GRHL2], Gene ID: 79977, NCBI: NP_079191.2, UniProt: Q6ISB3 |
Catalog # | MBS969960 |
Price | $160, $235 |
Order / More Info | GRHL2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |