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Antigenic Specificity | Phospho-perk (Ser555) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | humanpredicted: porcine, bovine, horse, sheep, rabbit, dog, chicken, Xenopus |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Peptide ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-perk (Ser555) Antibody detects endogenous levels of perk only when phosphorylated at Ser555. Description: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. |
Immunogen | Immunogen: A synthesized peptide derived from human perk around the phosphorylation site of Ser555. Tissue Specificity: Ubiquitous. A high level expression is seen in secretory tissues. |
Other Names | [DKFZp781H1925; E2AK3_HUMAN; EC 2.7.11.1; Eif2ak3; Eukaryotic translation initiation factor 2 alpha kinase 3; Eukaryotic translation initiation factor 2-alpha kinase 3; Heme regulated EIF2 alpha kinase; HRI; HsPEK; Pancreatic eIF2 alpha kinase; Pancreatic eIF2-alpha kinase; PEK; PRKR like endoplasmic reticulum kinase; PRKR-like endoplasmic reticulum kinase; WRS] |
Gene, Accession # | [perk], Gene ID: 9451, NCBI: NP_004827.4, UniProt: Q9NZJ5 |
Catalog # | MBS9610803 |
Price | $225, $280, $340 |
Order / More Info | Phospho-perk (Ser555) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |