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Antigenic Specificity | Cyclin O |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from DNA that arise through either misincorporation during replication or cytosine deamination. UNG2 can also be bound by the HIV-1 integrase and incorporated into the virion particle, suggesting that it is required to remove uracils from the viral genome. As the intrinsic antiviral protein APOBEC3G generates numerous uracils in the HIV genome during its replication, it may be that the UNG2 contributes to the APOBEC3G-mediated loss of infectivity by generating abasic sites in the vira |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 14 amino acid peptide from near the amino terminus of human UNG2. |
Other Names | [Uracil-DNA glycosylase 2, UDG2] |
Gene, Accession # | Gene ID: 10309, NCBI: NP_066970 |
Catalog # | MBS9403618 |
Price | $320 |
Order / More Info | Cyclin O Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |