Phospho-p16-INK4A (S140) Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Phospho-p16-INK4A (S140) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.31 |
| Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry - paraffin (IHC-P) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This p16-INK4A Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S140 of human p16-INK4A. p16-INK4A functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. This protein acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. The gene for this protein is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. |
| Immunogen | n/a |
| Other Names | [Cyclin-dependent kinase inhibitor 2A; isoforms 1/2/3; Cyclin-dependent kinase 4 inhibitor A; CDK4I; Multiple tumor suppressor 1; MTS-1; p16-INK4a; p16-INK4; p16INK4A; CDKN2A; CDKN2; MTS1] |
| Gene, Accession # | [CDKN2A], Gene ID: 1029, NCBI: NP_000068.1, UniProt: P42771 |
| Catalog # | MBS9202994 |
| Price | $165, $370 |
| Order / More Info | Phospho-p16-INK4A (S140) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Ausserlechner, M.J., et al., Leukemia 19(6):1051-1057 (2005). Kawamata, N., et al., Eur. J. Haematol. 74(5):424-429 (2005). Wang, J.L., et al., Mod. Pathol. 18(5):629-637 (2005). Kuroda, H., et al., Cancer Genet. Cytogenet. 158(2):172-179 (2005). Fu, G.H., et al., FEBS Lett. 579(10):2105-2110 (2005). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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