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Antigenic Specificity | Lambda Light Chain (B-Cell Marker) |
Clone | [N10/2] |
Host Species | Mouse |
Reactive Species | human. |
Isotype | IgG1, kappa |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant. |
Immunogen | Immunogen: Purified IgG from human serum Cellular Localization: Cell Surface, Cytoplasmic and secreted |
Other Names | [Bence Jones Protein; BJP; IGLC 1/2/3; Mcg Marker; Paraprotein] |
Gene, Accession # | [IGL], Gene ID: 449585; 3535; 3546, NCBI: P01701.2, UniProt: P01701 |
Catalog # | MBS4380045 |
Price | $190, $340, $340 |
Order / More Info | Lambda Light Chain (B-Cell Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Leung N et. al. Leuk Lymphoma doi:10.3109/10428194.2012.673229 (2012). Villaverde et al..Clin Kidney J 5:59-62 (2012). |