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Antigenic Specificity | CARD8 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total CARD8 protein. The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human CARD8. |
Other Names | [CARD8; CARDINAL; DACAR; DKFZp779L0366; Dakar] |
Gene, Accession # | [CARD8], Gene ID: 22900, NCBI: NP_001171829.1, UniProt: Q9Y2G2 |
Catalog # | MBS9409006 |
Price | $255 |
Order / More Info | CARD8 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |