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Antigenic Specificity | SOCS1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-211 of human SOCS1 (NP 003736.1). |
Other Names | [JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; TIP-3; SOCS-1] |
Gene, Accession # | [SOCS1], Gene ID: 8651, NCBI: NP_003736.1, UniProt: O15524 |
Catalog # | MBS8547018 |
Price | $280 |
Order / More Info | SOCS1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |