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Antigenic Specificity | erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)] |
Clone | polyclonal |
Host Species | Human |
Reactive Species | human |
Isotype | n/a |
Format | Protein A purified |
Size | 0.2 mg |
Concentration | n/a |
Applications | ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30% of invasive breast cancers and 70% of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder. Recombinant monoclonal antibody to erbB-2 (Her-2/neu). Manufactured using a Recombinant Platform with variable regions (i.e. specificity) from the therapeutic antibody 4D5-8 (trastuzumab). NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. |
Immunogen | Immunogen: A431 cells (human epidermoid carcinoma) (over)expressing EGFR. Chimeric Use Statement: NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. |
Other Names | [Metastatic lymph node gene 19 protein (MLN 19); Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; p185HER2], [ERBB2; ERBB2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; HER2; MLN19; NEU; NGL; MLN 19] |
Gene, Accession # | Gene ID: 2064, UniProt: P04626 |
Catalog # | MBS488049 |
Price | $425 |
Order / More Info | erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)] Antibody from MYBIOSOURCE INC. |
Product Specific References | Carter P, Presta L, Gorman CM, Ridgway JB, Henner D, Wong WL, Rowland AM, Kotts C, Carver ME, Shepard HM. Humanization of an anti-p185HER2 antibody for human cancer therapy. Proc Natl Acad Sci U S A. 1992 May 15; 89(10):4285-9. PMID:1350088 |