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Antigenic Specificity | Amyloid-beta (Phospho Thr743) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-Amyloid-beta (T743) Polyclonal Antibody detects endogenous levels of Amyloid-beta protein only when phosphorylated at T743. APP encodes a cell surface receptor and transmembrane precursor protein (amyloid beta precursor protein) that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in APP have been implicated in autosomal dominant Alzh |
Immunogen | Immunogen: Synthesized peptide derived from human Amyloid-beta around the phosphorylation site of T743 |
Other Names | [Rabbit Amyloid-beta (phospho Thr743); A4; AD1; Amyloid beta A4 protein; APPI; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II] |
Gene, Accession # | [ABPP], Gene ID: 351, NCBI: NP_000475.1, UniProt: P05067 |
Catalog # | MBS9701245 |
Price | $130, $220, $325 |
Order / More Info | Amyloid-beta (Phospho Thr743) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |