CD163, Human Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CD163, Human |
| Clone | RM3/1 |
| Host Species | Mouse |
| Reactive Species | reactivity: human. cross reactivity: mouse |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | F, Flow Cytometry (FC/FACS), FS, Immunoflurescence (IF), Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody RM3/1 recognizes CD163, a 130 kDa type I membrane glycoprotein, which is expressed exclusively in the monocyte/macrophage system. CD163 is a member of the cysteine-rich scavenger receptor superfamily. CD163 is an acute phase regulated receptor for the hemoglobin-haptoglobin complex. Another important function of CD163 seems to be in the adhesion of monocytes to activated endothelial cells. The expression levels of CD163 vary during the course of macrophage differentiation. The highest levels are found on tissue macrophages whereas bone marrow-derived cells are CD163 negative. CD163 positive cells include skin histiocytes, gut, Kupffer cells, and macrophages in spleen, thymus placenta and inflamed |
| Immunogen | Immunogen: Human monocytes (epitope recognized SRCR domain 9) |
| Other Names | [Scavenger receptor cysteine-rich type 1 protein M130, Hemoglobin scavenger receptor], [CD163; CD163; M130; MM130; M130; sCD163] |
| Gene, Accession # | [CD163], Gene ID: 9332, NCBI: CAB45233.1, UniProt: Q86VB7 |
| Catalog # | MBS584200 |
| Price | $555 |
| Order / More Info | CD163, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Zwadlo, G et al; A monoclonal antibody to a novel differentiation antigen on human macrophages associated with the down-regulatory phase of the inflammatory process. Expl Cell Biol 1987, 55: 295 2. H?gger, P et al; Identification of the integral membrane protein RM3/1 on human monocytes as a glucocorticoid-inducible member of the scavenger receptor cysteine-rich family (CD163). J Immunol 1998, 161: 1883 3. Droste, A et al; Shedding of CD163, a novel regulatory mechanism for a member of the scavenger receptor cysteine-rich family. Biochem Biophys Res Commun 1999, 256: 110 4. Frings, W et al; Only the soluble form of the scavenger receptor CD163 acts inhibitory on phorbol ester-activated T-lymphocytes, whereas membrane-bound protein has no effect. FEBS Lett 2002, 526: 93 5. Komohara, Y et al; AM-3K, an anti-macrophage antibody, recognizes CD163, a molecule associated with an anti-inflammatory macrophage phenotype. J Histochem Cytochem 2006, 54: 763 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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