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Antigenic Specificity | OPA1 |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | IgG |
Format | unconjugated |
Size | 0.1 mL |
Concentration | n/a |
Applications | Immunocytochemistry (ICC), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | OPA1 (optic atrophy protein 1) is a dynamin-related GTPase which forms a diffusion barrier for proteins stored in mitochondrial cristae and is critical to mitochondrial fusion as well as regulation of apoptosis. Intrinsic apoptotic signals mediated proteolytic processing leads OPA1 oligomers disassembly and caspase activator cytochrome C (CYCS) release into mitochondrial intermembrane spaces. Defects in OPA1 are a cause of optic atrophy type 1 (OPA1) as well as dominant optic atrophy plus syndrome (DOA+). |
Immunogen | Immunogen: A synthetic peptide made to an internal region within residues 500-600 of human OPA1. |
Other Names | [dynamin-like 120 kDa protein, mitochondrial isoform 1 preproprotein; Dynamin-like 120 kDa protein, mitochondrial; dynamin-like 120 kDa protein, mitochondrial; OPA1 mitochondrial dynamin like GTPase; Optic atrophy protein 1], [OPA1; OPA1; NPG; NTG; MGM1; BERHS; largeG; MTDPS14; KIAA0567] |
Gene, Accession # | [OPA1], Gene ID: 4976, NCBI: NP_056375.2, UniProt: O60313 |
Catalog # | MBS555954 |
Price | $490 |
Order / More Info | OPA1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |