CHFR Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CHFR |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: CHFR antibody detects endogenous levels of total CHFR. Function: E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to |
| Immunogen | Immunogen: A synthesized peptide Subcellular Location: Nucleus > PML Body. Tissue Specificity: Ubiquitous. Predicted Cross Reactivity: Pig, Bovine, Sheep, Rabbit, Dog, Xenopus Similarity: Pig (91%), Bovine (91%), Sheep (91%), Rabbit (100%), Dog (100%), Xenopus (82%) |
| Other Names | [Checkpoint with forkhead and ring finger domains; Checkpoint with forkhead and RING finger domains protein; Chfr; CHFR_HUMAN; E3 ubiquitin protein ligase CHFR; E3 ubiquitin-protein ligase CHFR; EC 6.3.2.; FLJ10796; FLJ33629; RING finger protein 196; RNF 116; RNF 196; RNF116; RNF196; Ubiquitin ligase protein] |
| Gene, Accession # | [CHFR], Gene ID: 55743, NCBI: NP_001154816.1, UniProt: Q96EP1 |
| Catalog # | MBS9606187 |
| Price | $240, $280 |
| Order / More Info | CHFR Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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