PML Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | PML |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: PML antibody detects endogenous levels of total PML. Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal r |
| Immunogen | Immunogen: A synthesized peptide derived from human PML Subcellular Location: Nucleus > Nucleoplasm. Cytoplasm. Nucleus > PML Body. Nucleus > Nucleolus. Endoplasmic Reticulum Membrane. Early Endosome Membrane. Sumoylated forms localize to the PML nuclear bodies. The B1 box and the RING finger are also required for this nuclear localization. Isoforms lacking a nuclear localization signal are cytoplasmic. Detected in the nucleolus after DNA damage. Sequestered in the cytoplasm by interaction with |
| Other Names | [Acure promyelocytic leukemia, inducer of; MYL; Pml; PML_HUMAN; PP8675; Probable transcription factor PML; Promyelocytic leukemia; Promyelocytic leukemia inducer of; Promyelocytic leukemia protein; Protein PML; RING finger protein 71; RNF 71; RNF71; TRIM 19; Tripartite motif protein TRIM19; Tripartite motif-containing protein 19] |
| Gene, Accession # | [PML], Gene ID: 5371, NCBI: NP_002666.1, UniProt: P29590 |
| Catalog # | MBS9606977 |
| Price | $240, $280 |
| Order / More Info | PML Antibody from MYBIOSOURCE INC. |
| Product Specific References | Wu D, Shao K, Zhou Q, Sun J, Wang Z, Yan F, Liu T, Wu X, Ye B, Huang H, Zhou Y; Journal: Cell Physiol Biochem. Autophagy and Ubiquitin-Mediated Proteolytic Degradation of PML/Rar Fusion Protein in Matrine-Induced Differentiation Sensitivity Recovery of ATRA-Resistant APL (NB4-LR1) Cells: in Vitro and in Vivo Studies. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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