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Antigenic Specificity | FLT3 (Ab-591) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total FLT3 protein. FLT3 encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopo |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around aa.589~593 (Y-F-Y-V-D) derived from Human FLT3. |
Other Names | [CD135; FLK-2; FLT-3; FLT3; STK-1] |
Gene, Accession # | [FLT3], Gene ID: 2322, NCBI: NP_004110.2, UniProt: P36888 |
Catalog # | MBS9403311 |
Price | $200, $255 |
Order / More Info | FLT3 (Ab-591) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |