Edit |   |
---|---|
Antigenic Specificity | ITGB4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 28-310 of human ITGB4 (NP 000204.3). |
Other Names | [CD104; GP150] |
Gene, Accession # | [ITGB4], Gene ID: 3691, NCBI: NP_000204.3, UniProt: P16144 |
Catalog # | MBS8544118 |
Price | $280 |
Order / More Info | ITGB4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |