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Antigenic Specificity | CD35 / CR1 (Follicular Dendritic Cell Marker) |
Clone | [CR1/802] |
Host Species | Mouse |
Reactive Species | human, baboon, monkey |
Isotype | IgG1, kappa |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1)/CD35. This MAb does not block CR1 activity. It is highly specific to CR1 and shows no cross-reaction with CR2. The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21+/CD35+/CD1a-. This MAb labels follicular dendritic cells and follicular dendritic cell sarcoma. |
Immunogen | Immunogen: Recombinant human CR1 protein |
Other Names | [C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen], [CR1; CR1; KN; C3BR; C4BR; CD35; C3BR] |
Gene, Accession # | [CR1], Gene ID: 1378, NCBI: NP_000564.2, UniProt: P17927 |
Catalog # | MBS438802 |
Price | $190, $340, $340 |
Order / More Info | CD35 / CR1 (Follicular Dendritic Cell Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Ahearn, J.M. and Fearon, D.T. 1989. Structure and function of the complement receptors, CR1 (CD35) and CR2 (CD21). Adv. Immunol. 46: 183-219 |