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Antigenic Specificity | CXCR4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 500 ug/ml |
Applications | Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Human immunodeficiency virus and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The alpha-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CX |
Immunogen | Immunogen: CXCR4 antibody was raised in Rabbit using synthetic peptide mapping to the N-terminus of human CXCR4 as the immunogen. |
Other Names | [Rabbit CXCR4; CXCR4; CXCR4; chemokine (C-X-C motif) receptor 4; CXC chemokine receptor; CXC chemokine receptor 4; CXCR 4; CXCR4; CXC chemokine receptor-4; CXCR-4; CXCR 4; CXCR-4] |
Gene, Accession # | [CXCR4], Gene ID: 7852 |
Catalog # | MBS5311623 |
Price | $475 |
Order / More Info | CXCR4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |