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Antigenic Specificity | BMI1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 120-326 of human BMI1 (NP 005171.4). |
Other Names | [PCGF4; RNF51; FLVI2/BMI1; flvi-2/bmi-1] |
Gene, Accession # | [BMI1], Gene ID: 648, NCBI: NP_005171.4, UniProt: P35226 |
Catalog # | MBS8543939 |
Price | $280 |
Order / More Info | BMI1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |