PUMA (CT) Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-PUMA (CT) antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | PUMA (CT) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.025 mg |
| Concentration | 1mg/mL |
| Applications | Western Blot (WB), Immunocytochemistry (ICC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Background Info: Detects a ~23kDa protein corresponding to the molecular mass of PUMA on SDS PAGE immunoblots. 16kDa bands may be seen in some instances, possibly corresponding to PUMAbeta. Scientific Background: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 up-regulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse (1-3). PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing pr |
| Immunogen | n/a |
| Other Names | [BBC3; BCL2 binding component 3; p53 up regulated modulator of apoptosis; PUMA/JFY1], [BBC3; BBC3; JFY1; PUMA; JFY-1; PUMA] |
| Gene, Accession # | Gene ID: 27113, NCBI: NP_001120712.1, UniProt: Q9BXH3 |
| Catalog # | MBS806717 |
| Price | $240 |
| Order / More Info | PUMA (CT) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell. 2001; 7(3):683-94. 2. Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001;7(3):673-82. 3. Han J, Flemington C, Houghton AB, Gu Z, Zambetti GP, Lutz RJ, Zhu L, Chittenden T. Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci U S A. 2001; 98(20):11318-23. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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