Edit |   |
---|---|
Antigenic Specificity | PUMA / bbc3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg |
Concentration | 0.5 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: PUMA (p53 upregulated modulator of apoptosis) is one of the pro-apoptotic Bcl-2 family members which are also transcriptional targets of p53. PUMA gene encodes two BH3 domain-containing proteins termed PUMA-alpha and PUMA-beta. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. |
Immunogen | Immunogen: Synthetic peptide surrounding amino acid 177 of human PUMA. Positive Control: Western Blot: Jurkat cells and Rat kidney tissue, IHC: Tonsil tissue |
Other Names | [PUMA/JFY1,JFY-1; PUMA; BBC3; bcl-2 binding component 3], [BBC3; BBC3; JFY1; PUMA; JFY-1; PUMA] |
Gene, Accession # | [PUMA/bbc3], Gene ID: 27113, NCBI: NP_001120712.1, UniProt: Q9BXH1 |
Catalog # | MBS840219 |
Price | $150, $290 |
Order / More Info | PUMA / bbc3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |