Phospho-JAK1 (Tyr1034/Tyr1035) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-JAK1 (Tyr1034/Tyr1035) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Phospho-JAK1 (Tyr1034/Tyr1035) antibody detects endogenous levels of JAK1 only when phosphorylated at Tyr1034/Tyr1035. Description: Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain.Function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529).Subunit Structure: Interacts with IL31RA (PubMed:15194700). Interacts with IFNAR2 (PubMed:7759950). Interacts with IFNGR1 (PubMed:7615558). Interacts with JAKMIP1 (PubMed:15277531). Interacts with SHB (Pub |
| Immunogen | Immunogen: A synthesized peptide derived from human JAK1 around the phosphorylation site of Tyr1034/Tyr1035 Subcellular Location: Endomembrane System. Wholly intracellular, possibly membrane associated. Tissue Specificity: Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus Si |
| Other Names | [JAK 1; JAK 1A; JAK 1B; JAK-1; JAK1; JAK1_HUMAN; JAK1A; JAK1B; Janus kinase 1 (a protein tyrosine kinase); Janus kinase 1; JTK3; Tyrosine protein kinase JAK 1; Tyrosine protein kinase JAK1; Tyrosine-protein kinase JAK1] |
| Gene, Accession # | [JAK1], Gene ID: 3716, NCBI: NP_001307852.1, UniProt: P23458 |
| Catalog # | MBS9600626 |
| Price | $240, $280 |
| Order / More Info | Phospho-JAK1 (Tyr1034/Tyr1035) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Bai Y, Wang J, Han J, Xie XL, Ji CG, Yin J, Chen L, Wang CK, Jiang XY, Qi W, Jiang HQ; Journal: Mol Carcinog. BCL2L10 inhibits growth and metastasis of hepatocellular carcinoma both in vitro and in vivo. Tu T, Yu M, Zhang Y, Shi X, Xu J, Hu J, Gan J, He W, Dong L, Han J, Huang Z, Pan Y, Zhang J; Journal: Biochem Pharmacol. A novel fluorinated triazole derivative suppresses macrophage activation and alleviates experimental colitis via a Twist1-dependent pathway. Chen L, Zhou D, Liu Z, Huang X, Liu Q, Kang Y, Chen Z, Guo Y, Zhu H, Sun C; Journal: Oncol Rep. Combination of gemcitabine and erlotinib inhibits recurrent pancreatic cancer growth in mice via the JAK-STAT pathway. |
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