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Antigenic Specificity | Cdc25B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Description: Rabbit IgG polyclonal antibody for M-phase inducer phosphatase 2(CDC25B) detection. Tested with WB, IHC-P in Human, Rat. Background: Central to the onset of mitosis in all eukaryotic cells is the CDC2 protein kinase, the activity of which is negatively regulated by phosphorylation and positively activated by dephosphorylation. The latter function is carried out by a specific phosphatase, CDC25. At least 3 human CDC25 genes code for the A, B, and C forms of CDC25. CDC25B is mapped to 20p13. P38 kinase has a critical role in the initiation of a G2 delay after ultraviolet radiation. Inhibition of p38 blocks the rapid initiation of this checkpoint in both human and murine cells after ultraviolet radiation. In vitro, p38 binds and p |
Immunogen | Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Cdc25B (541-559aa DYRPMNHEAFKDELKTFRL), different from the related mouse sequence by three amino acids. |
Other Names | [M-phase inducer phosphatase 2; cell division cycle 25 homolog B(S. pombe); AI604853; Cdc 25B; Cdc25b; CDC25B1; CDC25B2; CDC25B3; CDC25HU2; Cdc25m2; Cell division cycle 25 homolog B; Cell division cycle 25B; Cell division cycle 25B isoform 1; Cell division cycle 25B isoform 2; Cell division cycle 25B isoform 3; Cell division cycle 25B isoform 4; Dual specificity phosphatase Cdc25B; EC 3.1.3.48; M phase inducer phosphatase 2; M-phase inducer phosphatase 2; MPIP2_HUMAN], [CDC25B; CDC25B; CDC25HU2] |
Gene, Accession # | [CDC25B], Gene ID: 994, NCBI: P30305.2, UniProt: P30305 |
Catalog # | MBS175687 |
Price | $315 |
Order / More Info | Cdc25B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |