BIRC2 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | BIRC2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR (baculovirus inhibitor repeat) domain (1, 2). Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression (3-5). In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9 (5, 6). In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with c |
| Immunogen | Immunogen: Recombinant protein of human BIRC2 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [BIRC2; API1; HIAP2; Hiap-2; MIHB; RNF48; cIAP1] |
| Gene, Accession # | [BIRC2], Gene ID: 329, NCBI: NP_001157.1, UniProt: Q13490 |
| Catalog # | MBS8501330 |
| Price | $310 |
| Order / More Info | BIRC2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Deveraux, Q.L. and Reed, J.C. (1999) Genes Dev 13, 239-52. 2. Deveraux, Q.L. et al. (1998) EMBO J 17, 2215-23. 3. Altieri, D.C. et al. (1999) Lab Invest 79, 1327-33. 4. Tamm, I. et al. (2000) Clin Cancer Res 6, 1796-803. 5. Kasof, G.M. and Gomes, B.C. (2001) J BiolChem 276, 3238-46. 6. Deveraux, Q.L. et al. (1997) Nature 388, 300-4. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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