CrkL Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-CrkL antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | CrkL |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal to Human CrkL. CrkL, a 39 kDa adaptor protein, has a key regulatory role in hematopoietic cells. CrkL has one SH2 and two SH3 domains, with 60% homology to CrkII (1). The amino-terminal SH3 domain of CrkL binds proteins such as C3G, SOS, PI3K, c-Abl and BCR/Abl. The SH2 domain of CrkL can bind to tyrosine-phosphorylated proteins such as Cbl, HEF1, CAS and paxillin (2,3). CrkL is involved in various signaling cascades initiated by different cytokines and growth factors. The biological outcomes of the Crk-activated signal transduction include the modulation of cell adhesion, cell migration and immune cell responses (4). CrkL is a prominent substrate of the BCR/Abl oncoprotein in chronic myelogenous leukemia and binds to both |
| Immunogen | Immunogen: A synthetic -peptide of human CrkL |
| Other Names | [CRKL; CrkL; CrkL; A synthetic peptide of human CrkL], [CRKL; CRKL] |
| Gene, Accession # | Gene ID: 1399, NCBI: NP_005198.1, UniProt: P46109 |
| Catalog # | MBS125983 |
| Price | $200, $275, $430 |
| Order / More Info | CrkL Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Satter, M. and Salgia, R. (1998) Leukemia 12, 637-644. 2. Feller, S. M. et al. (1998) J. Cell. Physiol. 177, 535-552. 3. Kiyokawa, E. et al. (1997) Crit. Rev. Oncog. 8, 329-342. 4. Feller, S. M. et al. (2001) Oncogene 20, 6348-6371. 5. Grumbach, I. M. et al. (2001) Br. J. Haematol. 112, 327-336. 6. Nicholas, G. L. et al. (1994) Blood 84, 2912-2918. 7. de Jong, R. et al. (1997) Oncogene 14, 507-513. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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