P2RX4 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | P2RX4 |
| Clone | polyclonal |
| Host Species | n/a |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Description: Rabbit IgG polyclonal antibody for P2X purinoceptor 4(P2RX4) detection. Tested with WB in Human. Background: Purinoceptor P2X4, also called P2X4R is a protein that in humans is encoded by the P2RX4 gene. This gene belongs to the family of purinoceptors for ATP. P2RX4 was mapped to 12q24.32 by fluorescence in situ hybridization. P2RX4 is a receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. P2X4 receptor in hyperactive microglia is necessary for tactile allodynia after nerve injury and is sufficient to produce tactile allodynia in normal animals. P2X4 recetors have beeb implicated in the regulation of cardiac function, ATP-mediated cell death, synaptic stre |
| Immunogen | Immunogen: E Coli-derived human P2RX4 recombinant protein (Position: N262-Q388). Human P2RX4 shares 91% and 90% amino acid (aa) sequence identity with mouse and rat P2RX4, respectively. Ig Type: Rabbit IgG |
| Other Names | [P2X purinoceptor 4; AI504491; ATP gated cation channel protein; ATP receptor; AW555605; D5Ertd444e; MGC143034; OTTMUSP00000023741; OTTMUSP00000023745; OTTMUSP00000023746; OTTMUSP00000023747; p2rx4; P2RX4_HUMAN; P2X purinoceptor 4; P2X receptor subunit 4; P2X4; P2X4R; Purinergic receptor; Purinergic receptor P2X ligand gated ion channel 4; Purinergic receptor P2X4; Purinoceptor P2X4; purinergic receptor P2X, ligand gated ion channel, 4], [P2RX4; P2RX4; P2X4; P2X4R; P2X4] |
| Gene, Accession # | [P2RX4], Gene ID: 5025, NCBI: NP_001243725.1, UniProt: Q99571 |
| Catalog # | MBS178283 |
| Price | $280 |
| Order / More Info | P2RX4 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Adrian, K., Bernhard, M. K., Breitinger, H.-G., Ogilvie, A. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. Biochim. Biophys. Acta 1492: 127-138, 2000. 2. Kawate, T., Michel, J. C., Birdsong, W. T., Gouaux, E. Crystal structure of the ATP-gated P2X4 ion channel in the closed state. Nature 460: 592-598, 2009. 3. Wilson, S. G., Adam, G., Langdown, M., Reneland, R., Braun, A., Andrew, T., Surdulescu, G. L., Norberg, M., Dudbridge, F., Reed, P. W., Sambrook, P. N., Kleyn, P. W., Spector, T. D. Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in a female dizygous twin cohort. Europ. J. Hum. Genet. 14: 340-348, 2006. 4. Yamamoto, K., Sokabe, T., Matsumoto, T., Yoshimura, K., Shibata, M., Ohura, N., Fukuda, T., Sato, T., Sekine, K., Kato, S., Isshiki, M., Fujita, T., Kobayashi, M., Kawamura, K., Masuda, H., Kamiya, A., Ando, J. Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice. Nature Med. 12: 133-137, 2006. |
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