Edit |   |
---|---|
Antigenic Specificity | VRK2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks th |
Immunogen | Immunogen: Recombinant Human Serine/threonine-protein kinase VRK2 protein (317-472AA) |
Other Names | [Serine/threonine-protein kinase VRK2; Vaccinia-related kinase 2; VRK2] |
Gene, Accession # | [VRK2], Gene ID: 7444, NCBI: NP_001123952.1, UniProt: Q86Y07 |
Catalog # | MBS7109284 |
Price | $160, $235 |
Order / More Info | VRK2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |