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Antigenic Specificity | Human CD255 |
Clone | [4ACARL-2] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG3 |
Format | unconjugated |
Size | 100 tests, 500 tests |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), ELISA Capture (EIA), Neutralization |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | TNF-like weak inducer of apoptosis (TWEAK) is a type II transmembrane TNF superfamily member with strong homology to TNF in its extracellular portion, though less potent in inducing apoptosis. It has been clustered as CD255. TWEAK transcript is expressed broadly in many adult and fetal tissues; however, the staining of human peripheral blood mononuclear cells with TWEAK-specific antibodies shows a more restricted pattern. TWEAK is expressed as membrane-bound and secreted forms. Interaction of TWEAK with its receptors (DR3, Fn14) promotes secretion of IL-8, activation of NF-kappaB, proliferation of endothelial cells, and apoptosis in a number of human cell lines. The 4ACARL-2 antibody can neutralize the bioactivity of natural or recombinant |
Immunogen | n/a |
Other Names | n/a |
Gene, Accession # | [CD255] |
Catalog # | MBS8501532 |
Price | $280, $350 |
Order / More Info | Human CD255 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Fitzgerald, K., et al. Eds. 2001. The Cytokine FactsBook. Academic Press, San Diego. 2. Chicheportiche, Y., et al. 1997. J. Biol. Chem. 272:32401. 3. Kaplan, M., et al. 2000. J. Immunol. 164:2897. 4. Saas, P., et al. 2000. Glia 32:102. 5. Wiley, S., et al. 2001. Immunity 15:837. |