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Antigenic Specificity | Human CD45 RO |
Clone | [UCHL1] |
Host Species | Mouse |
Reactive Species | human, primate, monkey |
Isotype | IgG2a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | 1.0 mg/ml |
Applications | Flow Cytometry (FC/FACS), FPS |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Information: Human CD45 is expressed on all cells of hematopoietic origin, except erythrocytes. CD45 is a transmembrane tyrosine phosphatase which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments. The CD45RO isoform contains none of the alternatively spliced exons and is present on most thymocytes, a subpopulation of resting (memory) T cells within both CD4 and CD8 subsets as well as on monocytes and granulocytes. CD45RO plays an essential role in lymphocyte activation. Antibody UCHL1 recognizes the CD45RO isoform of about 180 kd. |
Immunogen | Immunogen: Cultured human T cell line-CA-1 |
Other Names | [human CD45RO/Biotin], [PTPRC; PTPRC; LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; CD45; L-CA] |
Gene, Accession # | [CD45], Gene ID: 5788, NCBI: AAS46946.1 |
Catalog # | MBS666195 |
Price | $310 |
Order / More Info | Human CD45 RO Antibody from MYBIOSOURCE INC. |
Product Specific References | S.H. Smith, et al, (1986) Immunology 58: 63-70. M. Streulo, et al, (1988) J Immunol 141: 3910-3914. M. Merkenschlager & P.C.L. Beverly, (1989) Intl Immunol 1: 450-459. I.S. Trowbridge & M.L. Thomas, (1994) Annu Rev Immunol 12: 85-116. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 386-399. D. Leitenberg, et al, (1996) J Exp Med 183: 249-259. |