CAD Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | CAD |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein A purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CAD (caspase-activated DNase), a 40 kDa nuclear protein, is primarily responsible for cell-autonomous DNA degradation during apoptosis. CAD is present in healthy cells where it is held in an inactive state through the association with its inhibitor ICAD. The ICAD protein is inactivated in apoptotic cells via caspase-3 cleavage thereby releasing CAD, which subsequently cleaves chromosomal DNA. CAD is a magnesium-dependent endonuclease specific for double stranded DNA that generates double strand breaks with 3'-hydroxyl ends. The nuclease preferentially attacks chromatin in the internucleosomal linker DNA. However, the nuclease hypersensitive sites can be detected and CAD is potentially involved in large-scale DNA fragmentation as well. CAD-m |
| Immunogen | Immunogen: CAD antibody was raised in Rabbit using a synthetic target peptide as the immunogen |
| Other Names | [Rabbit CAD; CAD; CAD; DFFB; DNA fragmentation factor; 40kDa; beta polypeptide (caspase-activated DNase); 40kDa; BOS_15888; Cad; caspase-activated deoxyribonuclease; caspase-activated DNase; caspase-activated nuclease; CH211-147A11.2; CPAN; DFF2; DFF40; DFF-40; Didff; DNA fragmentation factor 40 kDa subunit; DNA fragmentation factor; 40 kD; beta polypeptide; DNA fragmentation factor 40 kD beta polypeptide (caspase-activated DNase); DNA fragmentation factor; 40 kD; beta polypeptide (caspase-activated DNase); DNA fragmentation factor; 40 kD; beta subunit; DNA fragmentation factor; beta polypeptide (caspase-activated DNase); DNA fragmentation factor; beta subunit; DNA fragmentation factor subunit beta; DNA fragmentation factor subunit beta-like; DNase inhibited by DNA fragmentation factor; RP13-531C17.1; RP23-254N4.2] |
| Gene, Accession # | [CAD], Gene ID: 1677, NCBI: BAA32250.1 |
| Catalog # | MBS5310039 |
| Price | $375 |
| Order / More Info | CAD Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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