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Antigenic Specificity | NDRG1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | N-myc downstream-regulated gene 1 (NDRG1), also termed Cap43, Drg1, RTP/rit42, and Proxy-1, is a member of the NDRG family, which is composed of four members (NDRG1-4) that function in growth, differentiation, and cell survival (1-5). NDRG1 is ubiquitously expressed and highly responsive to a variety of stress signals including DNA damage (4), hypoxia (5), and elevated levels of nickel and calcium (2). Expression of NDRG1 is elevated in N-myc defective mice and is negatively regulated by N-and c-myc (1, 6). During DNA damage, NDRG1 is induced in a p53-dependent fashion and is necessary for p53-mediated apoptosis (4, 7). Research studies have shown that NDRG1 may also play a role in cancer progression by promoting differentiation, inhibiting |
Immunogen | Immunogen: Recombinant protein of human NDRG1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [CAP43; CMT4D; DRG1; GC4; HMSNL; NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5] |
Gene, Accession # | [NDRG1], Gene ID: 10397, NCBI: NP_001128714.1, UniProt: Q92597 |
Catalog # | MBS8502050 |
Price | $310 |
Order / More Info | NDRG1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Shimono, A. et al. (1999) MechDev 83, 39-52. 2. Zhou, D. et al. (1998) Cancer Res 58, 2182-9. 3. van Belzen, N. et al. (1997) Lab Invest 77, 85-92. 4. Kurdistani, S.K. et al. (1998) Cancer Res 58, 4439-44. 5. Park, H. et al. (2000) BiochemBiophys Res Commun 276, 321-8. 6. Li, J. and Kretzner, L. (2003) Mol Cell Biochem 250, 91-105. 7. Stein, S. et al. (2004) J BiolChem 279, 48930-40. 8. Maruyama, Y. et al. (2006) Cancer Res 66, 6233-42. 9. Nishio, S. et al. (2008) Cancer Lett 264, 36-43. 10. Kalaydjieva, L. et al. (2000) Am J Hum Genet 67, 47-58. 11. Okuda, T. et al. (2004) Mol Cell Biol 24, 3949-56. 12. Taketomi, Y. et al. (2007) J Immunol 178, 7042-53. 13. Murray, J.T. et al. (2004) Biochem J 384, 477-88. |