Human Notch2 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Human Notch2 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Human Notch2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Notch1 is a transmembrane protein functioning in development and the determination of cell fate (1). During maturation, the notch molecule is cleaved by a furin-like convertase at its extracellular domain (2). Upon binding to a ligand such as Delta1, or upon extracellular calcium depletion, the carboxy-terminal notch1 fragment is released and further cleaved between Gly1743 and Val1744 (3,4). The resulting activated cytosolic fragment translocates to the nucleus where it activates transcription. Notch2 is a member of Notch family and mutation in Notch2 is associated with Alagille syndrome (5). |
| Immunogen | Immunogen: A synthetic peptide of human Notch2 |
| Other Names | [Notch2 Rabbit pab], [NOTCH2; AGS2; hN2; Notch 2 intracellular domain] |
| Gene, Accession # | [Notch2], Gene ID: 4853, NCBI: NP_001186930.1, UniProt: Q04721 |
| Catalog # | MBS125369 |
| Price | $200, $275, $430 |
| Order / More Info | Human Notch2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Artavanis-Tsakonas, S. et al. (1999) Science 284, 770-6.2. Chan, Y.M. and Jan, Y.N. (1998) Cell 94, 423-6.3. Schroeter, E.H. et al. (1998) Nature 393, 382-6.4. Rand, M.D. et al. (2000) Mol Cell Biol 20, 1825-35.5. McDaniell, R. et al. (2006) Am J Hum Genet 79, 169-73. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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