Edit |   |
---|---|
Antigenic Specificity | FADD |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.02 mL, 0.06 mL, 0.12 mL |
Concentration | 1.5mg/mL |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. |
Immunogen | Immunogen: Recombinant protein of human FADD |
Other Names | [GIG3, MORT1] |
Gene, Accession # | [FADD], Gene ID: 8772, NCBI: CAG33019.1, UniProt: Q13158 |
Catalog # | MBS2517189 |
Price | $110, $150, $225 |
Order / More Info | FADD Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |