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Antigenic Specificity | Stat4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg |
Concentration | 0.5 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-alpha and form a heterodimer which is part of the ISGF3 transcription factor complex. Althomugh early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3beta appears to be activated by both while Stat3alpha is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways. |
Immunogen | Immunogen: Synthetic peptide surrounding amino acid 732 of rat Stat4 |
Other Names | [Signal transducer and activator of transcription 4; stat -4], [Stat4] |
Gene, Accession # | [Stat4], Gene ID: 367264, NCBI: NP_001012226 |
Catalog # | MBS840183 |
Price | $150, $290 |
Order / More Info | Stat4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |