Edit |   |
---|---|
Antigenic Specificity | Caspase 4 Picoband |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Description: Caspase 4 is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue, and belongs to a family of cysteine proteases called caspases. The Caspase 4 gene is mapped to a P1 clone containing the ICE gene, which is located at chromosome 11q22.2-q22.3. It contains 8 coding exons. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and the murine homolog caspase 11), with a role in the immune system.Protein Function: Inflammatory caspase (PubMed: 7797510, PubMed: 23516580, PubMed: 25119034). Essential effector of NLRP3 inflammasome- dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, su |
Immunogen | Immunogen: E Coli-derived human Caspase 4 recombinant protein (Position: H111-R194). Subcellular Localization: Cytoplasm, cytosol. Tissue Specificity: Widely expressed, including in keratinocytes and colonic and small intestinal epithelial cells (at protein level). Not detected in brain. |
Other Names | [Caspase-4; CASP-4] |
Gene, Accession # | [CASP4], Gene ID: 837, NCBI: NP_001216.1, UniProt: P49662 |
Catalog # | MBS1750802 |
Price | $315 |
Order / More Info | Caspase 4 Picoband Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |