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Antigenic Specificity | NONO |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | DNA-and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end join |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NONO (NP 001138881.1). |
Other Names | [P54; NMT55; NRB54; MRXS34; P54NRB; PPP1R114] |
Gene, Accession # | [NONO], Gene ID: 4841, NCBI: NP_001138880.1, UniProt: Q15233 |
Catalog # | MBS8545475 |
Price | $280 |
Order / More Info | NONO Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |