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Antigenic Specificity | TDP43 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: At least two isoforms are known to exist for this protein; this TDP43 antibody only recongizes the longer of the two isoforms. TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3' splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not re |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 18 amino acid peptide from near the center of human TDP43. |
Other Names | [TAR DNA binding protein, TARDBP] |
Gene, Accession # | [TDP43], NCBI: ABO32290 |
Catalog # | MBS9404360 |
Price | $320 |
Order / More Info | TDP43 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |