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Antigenic Specificity | Phospho-TLK1 (Ser743) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-TLK1 (Ser743) antibody detects endogenous levels of TLK1. Function: Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.Subunit Structure: Heterodimerizes with TLK2. Interacts with ASF1A and ASF1B.Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kina |
Immunogen | Immunogen: A synthesized peptide derived from human TLK1 around the phosphorylation site of Ser743. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken Similarity: Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit |
Other Names | [PKU beta; PKU-beta; serine threonine protein kinase; Serine/threonine protein kinase tousled like 1; Serine/threonine-protein kinase tousled-like 1; SNARE protein kinase SNAK; Tlk1; TLK1_HUMAN; Tousled like kinase 1; Tousled-like kinase 1] |
Gene, Accession # | [TLK1], Gene ID: 9874, NCBI: NP_001130026.1, UniProt: Q9UKI8 |
Catalog # | MBS9600753 |
Price | $240, $280 |
Order / More Info | Phospho-TLK1 (Ser743) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |