HspBP1 (FL4) Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-HspBP1 (FL4) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | HspBP1 (FL4) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.2 mg |
| Concentration | 0.200 mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Human HspBP1. HspBP1 is an Hsp70-interacting protein that was first isolated from a human heart cDNA library using the yeast two-hybrid system (1). The ATPase domain of Hsp70 binds HspBP1 and upon binding inhibits Hsp70 chaperone activity. More recently HspBP1 was found to be a homologue of the yeast Fes1 and Sls1 proteins and promotes nucleotide dissociation from Hsc70. HspBP1 has also been shown to strip nucleotide from yeast Ssa1p, making it a member of the class of nucleotide exchange factors that exhibit varying degrees of compartment and species specificity (2). HspBP1 is highly expressed in heart, brain, skeletal muscle, and pancreas tissues. It is also expressed in pancreatic, hepatic, and astrocytic cell lines. |
| Immunogen | Immunogen: a truncation mutant that cotains amino acids 84-359 of human recombinant HspBP1 (3). License: (FL4)HspBP1 is sold under License from Desert Genetics, Inc. under United States Patent 6,410,713 |
| Other Names | [HSPB1-associated protein 1; HSPB1-associated protein 1; HSPB1-associated protein 1; 27 kDa heat shock protein-associated protein 1; protein associating with small stress protein PASS1; HSPB (heat shock 27kDa) associated protein 1; 27 kDa heat shock protein-associated protein 1; Protein associated with small stress protein 1], [HSPBAP1; HSPBAP1; PASS1; PASS1] |
| Gene, Accession # | [HspBP1], Gene ID: 79663, NCBI: NP_078886.2, UniProt: Q96EW2 |
| Catalog # | MBS440079 |
| Price | $240 |
| Order / More Info | HspBP1 (FL4) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1.) Alberti S, Bohse K, Arndt V, Schmitz A, Hohfeld J. 2004. The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator. Mol Biol Cell. 2004 Sep;15(9):4003-10. 2.) Raynes DA, Thomson CA, Stroster J, Newton T, Cuneo P, Guerriero V. 2006. Human serum contains detectable levels of the Hsp70 cochaperone HspBP1 and antibodies bound to HspBP1. J Immunoassay Immunochem. 27(3):251-64.1. Raynes DA, Guerriero V Jr. 1998. Inhibition of Hsp70 ATPase activity and protein renaturation by a novel Hsp70-binding protein. J. Biol Chem. 273(49):32883-32888.2. Kabani M, McLellan C, Raynes DA, Guerriero V, Brodsky JL. 2002. HspBP1, a homologue of the yeast Fes1 and Sls1 proteins, is an Hsc-70 nucleotide exchange factor. FEBS Lett. 531(2):339-342.3. McLellan CA, Raynes DA, Guerriero V. 2003. HspBP1, an Hsp70 cochaperone, has two structural domains and is capable of altering the conformation of the Hsp70 ATPase domain. J. Biol. Chem. 278(21):19017-19022. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
Return to Antibodies