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Antigenic Specificity | UIMC1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total UIMC1 antibody. Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human UIMC1. |
Other Names | [RAP80; X2HRIP110] |
Gene, Accession # | [UIMC1], Gene ID: 51720, NCBI: NP_001186226.1, UniProt: Q96RL1 |
Catalog # | MBS9411681 |
Price | $255 |
Order / More Info | UIMC1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |