Smac/Diablo Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | Smac/Diablo |
| Clone | polyclonal |
| Host Species | n/a |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Description: Rabbit IgG polyclonal antibody for Diablo homolog, mitochondrial(DIABLO) detection. Tested with WB, IHC-P, ELISA in Human;Mouse;Rat. Background: Diablo homolog (DIABLO), also referred to as second mitochondria-derived activator of caspases or SMAC, is a mitochondrial protein that in humans is encoded by the DIABLO (direct IAP binding protein with low pI) gene on chromosome 12. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results |
| Immunogen | Immunogen: E Coli-derived human Smac/Diablo recombinant protein (Position: A56-D239). Human Smac/Diablo shares 88.6% amino acid (aa) sequence identity with human Smac/Diablo. Ig Type: Rabbit IgG |
| Other Names | [Diablo homolog; 0610041G12Rik; DBLOH_HUMAN; DBOH; diablo; Diablo homolog (Drosophila); Diablo homolog; Diablo homolog mitochondrial; DIABLO S; Direct IAP binding protein with low pI; Direct IAP-binding protein with low pI; FLJ10537; FLJ25049; mitochondrial; Mitochondrial Smac protein; Second mitochondria derived activator of caspase; Second mitochondria-derived activator of caspase; SMAC 3; Smac; Smac protein; SMAC3; diablo, IAP-binding mitochondrial protein], [DIABLO; DIABLO; SMAC; DFNA64; SMAC; Smac] |
| Gene, Accession # | Gene ID: 56616, NCBI: NP_001265231.1, UniProt: Q9NR28 |
| Catalog # | MBS178353 |
| Price | $315 |
| Order / More Info | Smac/Diablo Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Entrez Gene: DIABLO diablo homolog (Drosophila). 2. McNeish IA, Bell S, McKay T, Tenev T, Marani M, Lemoine NR (Jun 2003). Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis via a caspase-9-mediated pathway. Experimental Cell Research 286 (2): 186-98. 3. Yu J, Wang P, Ming L, Wood MA, Zhang L (Jun 2007). SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events. Oncogene 26 (29): 4189-98. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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