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Antigenic Specificity | HERC5 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | humanpredicted: bovine, horse, sheep |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: HERC5 Antibody detects endogenous levels of HERC5. Description: Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which resu |
Immunogen | Immunogen: A synthesized peptide derived from human HERC5. Tissue Specificity: Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels. |
Other Names | [CEB1; CEBP1; Cyclin E binding protein 1; Cyclin-E-binding protein 1; E3 ISG15--protein ligase HERC5; HECT domain and RCC1 like domain containing protein 5; HECT domain and RCC1-like domain-containing protein 5; Hect domain and RLD 5; HECT E3 ubiquitin ligase; HERC5; HERC5_HUMAN; Herc6] |
Gene, Accession # | [HERC5], Gene ID: 51191, NCBI: NP_057407, UniProt: Q9UII4 |
Catalog # | MBS9611809 |
Price | $240, $280 |
Order / More Info | HERC5 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |