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Antigenic Specificity | SHTN1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 0.8 mg/mL |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total SHTN1 protein. Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to prom |
Immunogen | Immunogen: Synthetic peptide of human SHTN1 Immunogen Type: Peptide |
Other Names | [KIAA1598; shootin-1] |
Gene, Accession # | [SHTN1], Gene ID: 57698, NCBI: NP_001120683.1, UniProt: A0MZ66 |
Catalog # | MBS9430677 |
Price | $255 |
Order / More Info | SHTN1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |